Comparative efficacy and safety of regimens including ritonavir-boosted lopinavir or nevirapine in antiretroviral-naïve HIV-1-infected individuals

of results LPV/r was given to 46.7%, whereas 53.3% received NVP. Average patient age was 42 years (range, 19-80), 23.4% were women and 72.5% Caucasians. Co-infection with hepatitis viruses was present in 34.1% of all patients. The first most frequently used NRTI backbone was zidovudine-lamivudine (84.4% all patients; 38.3% LPV/r; 46.1% NVP). An alteration on NRTI backbone without studydrug discontinuation was permitted. There were no statistically significant differences between groups in the former baseline variables. Patients receiving a LPV/ r-based regimen had, in average, lower baseline T CD4 cell counts (P=0.004, Mann-Withney) and a higher viral load (P<0.0001, Mann-Withney) compared with those receiving NVP. Early response to treatment was evaluated by the number of patients with a viral load decline >1.0 log10 after one month of treatment: 91.7% for LPV/r (n=33/36) and 77.1% for NVP (n=27/35). Undetectable viral load after one year of treatment was 79.3% for LPV/ r (n=46/58) and 82.8% for NVP (n=48/58); with an increase in T CD4 cell count by 8.9 and 1.9-fold for LPV/ r (n=46) and NVP (n=54), respectively (P=0.003). The overall number of patients that discontinued therapy before completing one year of treatment were, respectively for LPV/r and NVP, 17.9% (n=14/78) and 23.6% (n=21/89). Toxicity was the most referred reason for study-drug discontinuation in both groups. After one year of treatment, toxicity grade III/IV blood biochemistry analyzed values (serum transaminases, total cholesterol, HDL, LDL and triglycerides) were 10.2% (n=27/ 264) for LPV/r and 8.33% (24/288) for NVP, compared to 6.44% (n=17/264) and 7.99 % (n=23/288) on baseline.